San Giacomo del Colosseo was a mediaeval hospital church that used to stand right by the Colosseum at its east end. This is in the rione Campitelli.
The dedication was to St James the Great.
The small hospital of San Giacomo was first recorded in 1383, and became a dependency of the Lateran hospital in the following century. It was closed, and the church deconsecrated, at the end of the 16th century.
However the edifice survived, and is shown on the Nolli map of 1748 as a hay barn belonging to the larger hospital.
The complex was finally demolished in 1815, because its proximity to the Colosseum was deemed to be aesthetically unpleasing. 14th century wall paintings were recorded as uncovered during the demolition.
where its ruined outer wall terminates. It was not attached to the monument, although there was only a narrow gap between them.